Trial Information

Randomized Clinical Trial of Omega-3 Fatty Acid-supplemented Parenteral Nutrition Versus Standard Parenteral Nutrition in Patients Undergoing Major Laparoscopic Abdominal Surgery

Postoperative patients are randomized by a sealed envelope to receive either a 50:50
(vol/vol) mixture of an oil rich in medium-chain fatty acids and soybean oil (termed
MCT/LCT) or a mixture of MCT/LCT and fish oil Omegaven for 7 days. Full blood count,
biochemistry and coagulation are routinely assessed. Fresh blood samples are centrifuged
into plasma, red blood cells and lymphocytes then stored at −80°C pending analysis.

The primary endpoint was numbers of infective complications.Secondary endpoints were other
clinical outcomes, length of hospital stay, and in-hospital mortality, along with plasma
immunological markers.