Incidence of Respiratory Viral Infections During AML Induction and Consolidation Chemotherapy
Bacterial and fungal infection treatment is well defined with guidelines. Few data are
available for viral infections and concern essentially allogeneic stem cell transplantation.
These infections are associated with a high mortality and morbidity rate. Data concerning
AML are essentially retrospective, pediatric and with a little number of patients.
Respiratory viral infections incidence is not known. These infections may be responsible for
a higher mortality rate. Different risk factors are found: age superior to 65 years,
lymphopenia, co-infections. Treatment is subject to a controversy: surveillance or starting
an antiviral therapy. This study aims at understanding viral infections epidemiology during
long term aplasia and optimizing their management.
Intervention Model: Single Group Assignment, Masking: Open Label
positivity of the viral PCR in the presence of clinical signs during periods of positivity of the PCR in the presence of clinical signs
Positivity of the viral PCR in the presence of clinical signs during periods of Aplasia following chemotherapy induction and consolidation defining viral infection.
at day 15
Jean Pierre MAROLLEAU, MD PHD
France: Agence Nationale de Sécurité du Médicament et des produits de santé