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Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study


N/A
18 Years
75 Years
Not Enrolling
Female
Breast Cancer, Vitamin D Deficiency

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Trial Information

Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study


Background: The role of vitamin D in breast cancer prevention is equivocal. Saudi Arabian
women are thought to be at greater risk for vitamin D deficiency due to darker skin type and
greater likelihood for reduced UVB radiation exposure. However, there is a lack of data
regarding the vitamin D status of Saudi Arabian women and how this may relate to breast
cancer risk.

Objective: The purpose of this research was to evaluate the association between circulating
concentrations of 25(OH)D and breast cancer risk in Saudi Arabian women.

Design: A case-control study was conducted among 120 breast cancer cases and 120 controls.
The study population was drawn from patients admitted to King Fahd Hospital in Jeddah, Saudi
Arabia from June to August 2009. Participants completed questionnaires on diet and medical
history and serum samples were collected from all women to measure circulating 25(OH)D
concentrations.


Inclusion Criteria:



- Invasive breast cancer (cases) or healthy women (controls),

- receiving standard medical check-ups at the women's clinic

- Female,

- between the ages of 18 and 75 years

- BMI ≤ 40 kg/m2

- residence in Saudi Arabia for more than 5 years

- absence of chronic diseases that could affect vitamin D metabolism, including renal,
hepatic, endocrine, or autoimmune disease.

Exclusion Criteria:

receiving standard medical check-ups at the women's clinic

- Male,

- less than 18 or greater than 75 years of age

- BMI > 40 kg/m2

- Not a resident of Saudi Arabia for more than 5 years

- Presence of chronic diseases that could affect vitamin D metabolism, including renal,
hepatic, endocrine, or autoimmune disease.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

serum vitamin D

Outcome Description:

assessed serum vitamin D in cases versus controls

Outcome Time Frame:

cross-sectional from May 2009-August 2009

Safety Issue:

No

Principal Investigator

Cynthia A Thomson, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Arizona

Authority:

United States: Institutional Review Board

Study ID:

SAVitaminD

NCT ID:

NCT01817231

Start Date:

May 2009

Completion Date:

August 2009

Related Keywords:

  • Breast Cancer
  • Vitamin D Deficiency
  • breast cancer
  • vitamin D
  • 25 OH vitamin D
  • Breast Neoplasms
  • Vitamin D Deficiency

Name

Location

University of ArizonaTucson, Arizona  85724