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Identify Clinical Conditions That Increase Circulating DNA Levels


N/A
18 Years
80 Years
Open (Enrolling)
Both
Pregnancy, Pulmonary Embolism, Myocardial Infarction, Autoimmune Disease

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Trial Information

Identify Clinical Conditions That Increase Circulating DNA Levels


The investigator will collect 8 mL (one and one half teaspoons) of blood one time only. The
investigator may also collect the patient's past medical history, test results and disease
treatment.


Inclusion Criteria:



1. Patients must be adults in one of the following categories:

- Pregnant

- Suffered a pulmonary embolism within the past 48 hours

- Myocardial infarction in the past 48 hours

- Diagnosed with an autoimmune disease

- Adults age 18-80

- Self-declared healthy adults

2. Patients must be willing to undergo a blood draw

3. Patients must provide study-specific informed consent prior to study entry

Exclusion Criteria:

1. Patients not meeting the above inclusion criteria

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Different diseases will be analysed for the levels of DNA circulating in the blood

Outcome Description:

To determine what medical conditions and disease states might increase circulating DNA levels at a magnitude similar to whole body irradiation.

Outcome Time Frame:

blood will be tested up to 1 year after collection

Safety Issue:

No

Principal Investigator

Paul Okunieff, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Florida

Authority:

United States: Institutional Review Board

Study ID:

407-2012

NCT ID:

NCT01815996

Start Date:

October 2012

Completion Date:

September 2016

Related Keywords:

  • Pregnancy
  • Pulmonary Embolism
  • Myocardial Infarction
  • Autoimmune Disease
  • Pregnancy
  • pulmonary embolism
  • myocardial infarction
  • autoimmune disease
  • healthy controls
  • Autoimmune Diseases
  • Embolism
  • Infarction
  • Myocardial Infarction
  • Pulmonary Embolism

Name

Location

Shands Davis Cancer CenterGainesville, Florida  32610