Know Cancer

or
forgot password

Benefit of MRI and 18F-FDG PET Imaging in the Early Diagnosis of Alzheimer-like Dementia


N/A
65 Years
N/A
Open (Enrolling)
Both
Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia

Thank you

Trial Information

Benefit of MRI and 18F-FDG PET Imaging in the Early Diagnosis of Alzheimer-like Dementia


Inclusion Criteria:



- Age: over 65

- Participants (or representatives) gave their written informed consent

- Dementia diagnosed according to Diagnostic and Statistical Manual of Mental Disorders
(DSM IV) criteria

- For Alzheimer arm: probable Alzheimer based disease according to NINCDS-ADRDA
(National Institute of Neurological and Communicative Disorders and Stroke and the
Alzheimer's Disease and Related Disorders Association ) criteria

- For vascular dementia: diagnosis based on NINDS-AIREN (National Institute of
Neurological Disorders and Stroke and Association Internationale pour la Recherche et
l'Enseignement en Neurosciences) criteria

- For MCI: diagnosis based on Petersen index

Exclusion Criteria:

- Claustrophobia

- Diabetes

- Cardiovascular disease

- Glycemia over 1.3 g/L

- Lumbar puncture within one week before MRI examination

- Non MR-compatible implant

- Suspected brain metastases

- No informed consent signature

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic

Outcome Measure:

Dynamic FDG (fluoro-deoxyglucose) PET

Outcome Description:

Extraction of tissue time-activity curves ; notably in choroid plexus.

Outcome Time Frame:

Day 2

Safety Issue:

No

Principal Investigator

Marc-Etienne MEYER, MD,PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

CHU Amiens

Authority:

France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:

PI07-PR-MEYER1

NCT ID:

NCT01815112

Start Date:

February 2008

Completion Date:

July 2015

Related Keywords:

  • Alzheimer Disease
  • Mild Cognitive Impairment
  • Vascular Dementia
  • Neurodegenerative disease
  • Elderly
  • Dementia
  • FDG-PET
  • MRI
  • Neuroimaging
  • Alzheimer Disease
  • Dementia
  • Dementia, Vascular
  • Cognition Disorders

Name

Location