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Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels


N/A
18 Years
65 Years
Open (Enrolling)
Both
Thyroid Cancer, Breast Cancer

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Trial Information

Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels


This study has been done to further study the effectiveness of dexamethasone in the
prevention of postoperative emesis after breast and thyroid surgery and at the same time,
the mechanism of action was investigated. In this prospective, randomized controlled trial
it was hypothesized that corticosteroids exert their antiemetic effects in postoperative
period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4)
inhibition.


Inclusion Criteria:



- breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage
heallthy volunteers, signed the informed consent

Exclusion Criteria:

- ones who did not sign the consent form NSAID or steroid users

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis

Outcome Description:

participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.

Outcome Time Frame:

up to 3 days

Safety Issue:

Yes

Principal Investigator

A.Ozdemir Aktan, MD,prof

Investigator Role:

Principal Investigator

Investigator Affiliation:

Marmara University

Authority:

Turkey: Ethics Committee

Study ID:

09.2011.0024

NCT ID:

NCT01811199

Start Date:

February 2011

Completion Date:

May 2013

Related Keywords:

  • Thyroid Cancer
  • Breast Cancer
  • Thyroid cancer
  • Breast cancer
  • Dexamethasone
  • Emesis
  • Breast Neoplasms
  • Thyroid Neoplasms
  • Thyroid Diseases
  • Postoperative Nausea and Vomiting

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