Inclusion Criteria:

- Age greater than 18 years with no upper age limit

- Competent adult patient.

- Patient affiliated to the National Health Insurance.

- Patient with an intra-cerebral supra-tentorial hemispheric, newly diagnosed and
previously untreated, which MRI characteristics are suggestive of a glioblastoma.

- Indication for surgical treatment by excision.

- Brain tumor location distant from critical functional areas allowing a wide resection
of contrast enhancement on imaging, the a priori character completely resectable has
been validated by an evaluation committee composed of three surgeons

- No-cons contain medical surgery, ASA score below 4.

- Patient eligible for further treatment by radiotherapy and concurrent chemotherapy
followed by adjuvant chemotherapy according to the so called Stupp scheme (standard
protocol of adjuvant chemoradiotherapy)

- Negative pregnancy test for women of childbearing age.

Exclusion Criteria:

- Contraindications to performing an MRI (pacemaker).

- Glioblastoma known and previously treated with surgery, radiotherapy and / or
chemotherapy.

- History of cancer.

- Anatomical Location of the tumor-cons indicating a wide excision, neurosurgeon
at the discretion of medical officer participating center.

- Location tumor in the brain stem, the middle line, the basal ganglia and the
posterior cranial fossa.

- Patient with cons-indication to the achievement of further treatment with
radiotherapy and concurrent chemotherapy followed by adjuvant chemotherapy
according to the scheme proposed by Stupp. (1)

- Patients with porphyria, renal insufficiency (creatinine> 177 μmolL), liver
insufficency(gamma glutamyl transpeptidase> 100 U / L, prothrombin time <60%,
bilirubin> 51μmol / L).

- Patient refused to sign an informed consent form.

- Ongoing participation of the patient to another clinical trial.