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Study of Microcirculatory Effects of Bevacizumab in Patients Treated for Metastatic Colon Cancer or Glioblastoma


N/A
18 Years
N/A
Not Enrolling
Both
Metastatic Colorectal Cancer, Glioblastoma, Bevacizumab, Capillaroscopy

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Trial Information

Study of Microcirculatory Effects of Bevacizumab in Patients Treated for Metastatic Colon Cancer or Glioblastoma


Inclusion Criteria:



- Age ≥ 18 years

- signed informed Consent

- Medical Examination

- Patients with metastatic colorectal cancer

- Patients with a glioblastoma

- patient to receive treatment with bevacizumab not yet started

- MRI for patients with glioblastoma or scanner TAP for patients carrying a metastatic
colon cancer performed within 3 weeks before inclusion.

Exclusion Criteria:

- Bevacizumab already initiated or history of antiangiogenic treatment

- Inability legal (persons deprived of liberty or under guardianship)

- Pregnant or lactating women

- Can not sign consent or unable to undergo medical follow up for geographical, social
or psychological reasons

- Patients not covered by Medicare including CMU

- Estimated life of over 3 months

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

change in the density of capillaries

Outcome Description:

The change in the density of capillaries visualized by periungual capillaroscopy will be quantify after 15 days of treatment with bevacizumab, in patients with metastatic colon cancer or a brain tumor.

Outcome Time Frame:

baseline and after 15 days of bevacizumab treatment

Safety Issue:

No

Principal Investigator

François Ghiringhelli, Professor

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre Georges Francois Leclerc

Authority:

France: Agence Nationale de Sécurité du Médicament et des produits de santé

Study ID:

001-FANI-2012

NCT ID:

NCT01810744

Start Date:

April 2014

Completion Date:

Related Keywords:

  • Metastatic Colorectal Cancer
  • Glioblastoma
  • Bevacizumab
  • Capillaroscopy
  • Colonic Neoplasms
  • Colorectal Neoplasms
  • Glioblastoma

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