Inclusion Criteria:

- Patients have cutaneous warts, including common warts(d≥1cm or n≥5 ), plantar warts,
periungual warts, mosaic warts, which are suitable for cryotherapy and laser
treatment .

- patients aged eighting years and over, who have junior school degree or above

Exclusion Criteria:

- Patients who have more than 20 warts

- Patients who are currently participating in another trial for the treatment of their
warts

- Patients who took immunosuppressant drugs such as oral corticosteroids within the
past three months.

- Patients who are pregnant or ready for pregnancies or breast-feeding.

- Patients who have impaired healing eg due to diabetes, vascular disease, vitamin A
deficiency, hyperthyroidism and hypothyroidism.

- Patients who have autoimmune diseases, eg SLE, dermatomyositis, scleroderma and other
diseases .

- Patients who have cold intolerance, eg cold urticaria, cryoglobulinaemia, cold
agglutinin syndrome, Raynaud's syndrome.

- Patients who have local injections intolerance.

- Patients who have local hypoesthesia .

- Patients who can not tolerate cryotherapy or laser treatment for their own reasons.