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OBSERVATIONAL: A Genome-Wide Association Study in Wilms Tumor


N/A
N/A
N/A
Open (Enrolling)
Both
Recurrent Wilms Tumor and Other Childhood Kidney Tumors, Stage I Wilms Tumor, Stage II Wilms Tumor, Stage III Wilms Tumor, Stage IV Wilms Tumor

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Trial Information

OBSERVATIONAL: A Genome-Wide Association Study in Wilms Tumor


Study Subtype: Ancillary/Correlative Observational Study Model: Case-control Time
Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description:
DNA samples Study Population Description: Samples from the National Wilms Tumor Study Group
(NWTSG) Sampling Method: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To use a genome-wide association analysis to identify novel genetic variants that confer
susceptibility to Wilms tumor.

II. To improve our understanding of the genetic architecture and etiology of Wilms tumor.

III. To facilitate the identification of genetic markers that are associated with an
increased risk of developing of Wilms tumor and/or those at risk of aggressive disease,
relapse, additional tumors and/or cancer in their offspring.

OUTLINE:

Samples are analyzed for single nucleotide polymorphism (SNP) profiling using real-time
polymerase chain reaction (PCR) and multiplex ligation-dependent probe amplification (MLPA).


Inclusion Criteria:



- 3000 samples from the 1958 Birth Cohort (58C) and 3000 from the UK Blood Service
control series (NBS)

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Retrospective

Outcome Measure:

Use a genome-wide association analysis to identify novel genetic variants that confer susceptibility to Wilms tumor

Outcome Description:

Genotype 2000 cases using the Illumina Human660W-Quad BeadChip. This will include 1000 UK cases and 1000 US cases. Genotypes will be compared respectively with existing data from 4500 UK controls and 2000 US controls

Outcome Time Frame:

Baseline

Safety Issue:

No

Principal Investigator

Paul Grundy

Investigator Role:

Principal Investigator

Investigator Affiliation:

Children's Oncology Group

Authority:

United States: Food and Drug Administration

Study ID:

AREN09B1

NCT ID:

NCT01808079

Start Date:

November 2009

Completion Date:

Related Keywords:

  • Recurrent Wilms Tumor and Other Childhood Kidney Tumors
  • Stage I Wilms Tumor
  • Stage II Wilms Tumor
  • Stage III Wilms Tumor
  • Stage IV Wilms Tumor
  • Kidney Neoplasms
  • Wilms Tumor

Name

Location

Children's Oncology GroupArcadia, California  91006-3776