OBSERVATIONAL: A Genome-Wide Association Study in Wilms Tumor
Study Subtype: Ancillary/Correlative Observational Study Model: Case-control Time
Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description:
DNA samples Study Population Description: Samples from the National Wilms Tumor Study Group
(NWTSG) Sampling Method: Non-Probability Sample
I. To use a genome-wide association analysis to identify novel genetic variants that confer
susceptibility to Wilms tumor.
II. To improve our understanding of the genetic architecture and etiology of Wilms tumor.
III. To facilitate the identification of genetic markers that are associated with an
increased risk of developing of Wilms tumor and/or those at risk of aggressive disease,
relapse, additional tumors and/or cancer in their offspring.
Samples are analyzed for single nucleotide polymorphism (SNP) profiling using real-time
polymerase chain reaction (PCR) and multiplex ligation-dependent probe amplification (MLPA).
Observational Model: Case Control, Time Perspective: Retrospective
Use a genome-wide association analysis to identify novel genetic variants that confer susceptibility to Wilms tumor
Genotype 2000 cases using the Illumina Human660W-Quad BeadChip. This will include 1000 UK cases and 1000 US cases. Genotypes will be compared respectively with existing data from 4500 UK controls and 2000 US controls
Children's Oncology Group
United States: Food and Drug Administration
|Children's Oncology Group||Arcadia, California 91006-3776|