Trial Information

OBSERVATIONAL: A Genome-Wide Association Study in Wilms Tumor

Study Subtype: Ancillary/Correlative Observational Study Model: Case-control Time
Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description:
DNA samples Study Population Description: Samples from the National Wilms Tumor Study Group
(NWTSG) Sampling Method: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To use a genome-wide association analysis to identify novel genetic variants that confer
susceptibility to Wilms tumor.

II. To improve our understanding of the genetic architecture and etiology of Wilms tumor.

III. To facilitate the identification of genetic markers that are associated with an
increased risk of developing of Wilms tumor and/or those at risk of aggressive disease,
relapse, additional tumors and/or cancer in their offspring.

OUTLINE:

Samples are analyzed for single nucleotide polymorphism (SNP) profiling using real-time
polymerase chain reaction (PCR) and multiplex ligation-dependent probe amplification (MLPA).