Haploidentical Stem Cell Transplantation Followed by NK Cell Infusion in Patients With High-risk Solid Tumors Who Failed Autologous Stem Cell Transplantation
HaploSCT following reduced-intensity conditioning (RIC) regimen will be performed in
patients with high-risk solid tumors. Both parents will be evaluated for their KIR genotype
and phenotype and the one with the greatest degree of KIR-L mismatch with the patient will
be selected as the donor. In addition, ex-vivo expanded NK cells derived from the donor will
then be administered after haploSCT to increase the GVT effect. Low-dose IL-2 will be given
after expanded NK cell infusion to enhance NK cell alloreactivity.
Interventional
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Number of study patients with adverse events as a measure of safety of haploidentical stem cell transplantation and NK cell infusion
within 30 days after transplantation
Yes
Ki Woong Sung, MD, PhD
Principal Investigator
Department of Pediatrics, Samsung Medical Center
Korea: Food and Drug Administration
CR0113061
NCT01807468
May 2013
December 2018
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