Observational - Tissue Factor Expression in Bone Sarcomas
STUDY SUBTYPE: Ancillary/Correlative
OBSERVATIONAL STUDY MODEL: Case-only
TIME PERSPECTIVE: Retrospective
BIOSPECIMEN RETENTION: Samples without DNA
BIOSPECIMEN DESCRIPTION: Tissue samples obtained from Cooperative Human Tissue Network
STUDY POPULATION DESCRIPTION: Patients enrolled on P9754 and AOST0121 clinical trials
SAMPLING METHOD: Non-probability sample
I. To determine if there is differential expression of tumor factor (TF) among patients with
II. To determine if there is an association between overall survival and disease free
survival and the extent of TF expression.
III. To determine if TF expression correlates with presence of gross metastatic disease at
presentation, and development of subsequent metastases.
Tissue samples are analyzed for tumor factor expression levels by immunohistochemistry.
Observational Model: Case-Only, Time Perspective: Retrospective
Prevalence of high TF expression
Estimated in the analytic population as the number of samples in the population in which such expression is noted divided by 33. An assessment of the precision of such estimates will be provided by an exact binomial confidence interval. Comparison of normalized TF expression in non-metastatic versus metastatic patients will be done using the two-sample t-test.
Children's Oncology Group
United States: Institutional Review Board
|Children's Oncology Group||Arcadia, California 91006-3776|