Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma- A Randomized Multicenter Trial
Multicentre, randomized (1:1), double blinded trial:- Arm A: Standard of care (Radiotherapy
with concomitant temozolomide followed by monthly cures of temozolomide ) + Losartan
50mg*2/day until the halting for any reason - Arm B: Standard of care (Radiotherapy with
concomitant temozolomide followed by monthly cures of temozolomide + Placebo 2/day until the
halting for any reason.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Steroid dosage required to control brain edema on the last day of radiotherapy in each arm
Up to Day 42+ 1 month
Yes
Antoine CARPENTIER, MD, PhD
Principal Investigator
Assistance Publique - Hôpitaux de Paris
France: Ministry of Health
P120105
NCT01805453
March 2013
May 2014
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