Diagnostic Performance and Evaluation Efficacy of Brain 68Ga-BNOTA-PRGD2 PET/CT in Pre-surgery Glioma Patients
Integrin αvβ3 is an important member of integrin receptor family and expressed
preferentially on various types of tumor cells and the activated endothelial cells of tumor
angiogenesis, but not or very low on the quiescent vessel cells and other normal cells.
Therefore, the integrin αvβ3 receptor is becoming a valuable target for diagnosis and
response evaluation of malignant tumors.
The tri-peptide sequence of arginine-glycine-aspartic acid (RGD) can specifically bind to
the integrin αvβ3 receptor. Accordingly, a variety of radio-labeled RGD-based peptides have
been developed for non-invasive imaging of integrin αvβ3 receptor expression via positron
emission tomography (PET) or single photon emission computed tomography (SPECT). Among all
RGD radiotracers, several PET imaging agents, including 18F-Galacto-RGD and 18F-AH111585,
have been investigated in clinical trials for tumor diagnosis, and the results demonstrated
that both radiotracers allowed the specific imaging of various types of tumors, and the
tumor uptake correlated well with the expression of integrin αvβ3. Recently, serial RGD
dimeric peptides with PEG linkers have been studied. The new types of RGD peptides showed
much higher in vitro integrin αvβ3-binding affinity than the single RGD tri-peptide
sequence, and importantly, they exhibited significantly increased tumor uptake and improved
in vivo kinetics in animal models. As a representative, 68Ga-BNOTA-PRGD2 could be easily
prepared and exhibited excellent in vivo behaviors in animal models. No adverse reactions
have been observed in animal models to date.
For the further interests in clinical translation of 68Ga-BNOTA-PRGD2, an open-label brain
PET/CT study was designed to investigate the diagnostic performance and evaluation efficacy
of 68Ga-BNOTA-PRGD2 in pre-surgery glioma patients.
Interventional
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Semiquantitative measurement of standardized uptake values (SUVs) of lesions
The semiquantitative analysis will be performed by the same person for all cases, and the standardized uptake value (SUV) of each tumor will be measured using a volume of interest (VOI) method.
1 year
No
Zhaohui Zhu, MD
Principal Investigator
Peking Union Medical College Hospital
China: Ministry of Health
PUMCHNM6
NCT01801371
October 2012
December 2014
Name | Location |
---|