Inclusion Criteria:

- Written informed consent

- Male and female patients aged 18 years or older

- A history of uveal (ocular) melanoma with biopsy-confirmed metastatic disease

- Consent to providing 3 tumor biopsy samples throughout the course of the study

- Presence of measurable disease

- A WHO performance status of less than or equal to 1

Exclusion Criteria:

- Presence of CNS lesions (stable lesions may be acceptable)

- Previous or concurrent malignancy, other than basal cell or squamous cell carcinoma
of the skin: in situ carcinoma of the cervix, without evidence of recurrence for at
least 3 years; a primary malignancy completely resected and no evidence of recurrence
for at least 3 years

- Adverse event from prior chemotherapy, radiotherapy or surgery that has not recovered
to CTCAE v4.03 Grade 1 or less, except for alopecia/sensory peripheral neuropathy,
which must be less than Grade 2

- History or current evidence of central serous retinopathy (CSR) or retinal vein
occlusion (RVO) or any predisposing factor to CSR/RVO

- History of retinal degenerative disease

- Impaired cardiac function or clinically significant cardiac disease

- Impaired GI function or disease that could interfere with the absorption of AEB071
and/or MEK162

- Treatment with medicines or herbal supplements that are known inhibitors or inducers
of CYP3A4/5 and cannot be withdrawn prior to study treatment

- Females of child-bearing potential who are unwilling or unable to use highly
effective means of contraception

- Males who are unwilling or unable to use a condom during sexual intercourse

- Prior exposure to a MEK or PKC inhibitor Other inclusion/exclusion criteria apply