The Impact of Nursing and Pharmacy Care Between Xeloda® and 5-Fluoruracil Regimens in the Management of Colorectal Cancer (CRC) in Hong Kong
Colorectal cancer (CRC) is the second most common cause of cancer-related death in Hong
Kong. The traditional chemotherapy for CRC remains on intravenous (IV) fluorouracil (5-FU)
based regimens with the response rates of 10-20% and a median survival of approximately one
year. Recent years, oral chemotherapy has a more practical and economic advantages over IV
regimen. It is understandable that patients prefer oral regimens as long as the clinical
efficacy is maintained. Oral treatment strategy preserves quality of life for CRC patients.
In a previous cost-minimization study conducted in Hong Kong, it was demonstrated that
capecitabine was more cost-effective than 5-FU plus oxaliplatin assuming they had equal
clinical efficacy. Not only is capecitabine more cost-effective, it may also have
additional cost saving in the nursing and pharmacy time . It is because a significant
amount of time can be saved in both nursing and pharmacy for the preparation and
administration of IV chemotherapy. In the UK, it was demonstrated that capecitabine
required less pharmacy and administration time per cycle than 5-FU based IV chemotherapy.
However, there is a lack of local data to demonstrate the impact of pharmacy and nursing
care utilizing capecitabine comparing to traditional IV chemotherapy in CRC patients of Hong
Observational Model: Cohort, Time Perspective: Prospective
Composite preparation, dispensing and administration time
Composite time is measured via real-time recording. Total length of the said time points are to be recorded using a stop-watch and the sum is tabulated in the end.
Up to 6 months after the initiation of chemotherapy
Vivian WY Lee, PharmD
Hong Kong: Ethics Committee