Exploring Current Smokers' Interest in Using Smokeless Tobacco Products Smokeless Tobacco Substitution for Cigarettes
I. Systematically vary price, availability, product type, and information about products to
examine their individual and joint effects on degree of substitution of smokeless products
II. Examine the impact of smokeless tobacco (ST) substitution on biomarkers of exposure
(carbon monoxide [CO], cotinine).
III. Explore relationships between ST substitution and measures of mood and health related
quality of life.
OUTLINE: Participants are randomized to 1 of 2 treatment arms.
ARM I: Participants purchase ST products using a fixed rate of product prices once weekly
and record their consumption of ST products and cigarettes smoked daily for 3 weeks.
ARM II: Participants purchase ST products using escalating product prices once weekly and
record their consumption of ST products and cigarettes smoked daily for 3 weeks.
After completion of study treatment, patients are followed up for 6 months.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Proportion of tobacco use accounted for by ST
Tested using hierarchical linear modeling and generalized estimating equations.
Up to week 5
Roswell Park Cancer Institute
United States: Institutional Review Board
|Roswell Park Cancer Institute||Buffalo, New York 14263|