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Reducing Work Disability in Breast Cancer Survivors

25 Years
64 Years
Open (Enrolling)
Breast Cancer, Cancer Survivor

Thank you

Trial Information

Reducing Work Disability in Breast Cancer Survivors


I. Determine the feasibility and usability of the Work Ability Improvement Through Symptom
Management and Ergonomic Strategies (WISE) and empirically evaluate its effect on short-term
work ability among breast cancer survivors (BCS).


I. Explore individual and workplace factors associated with work ability in BCS.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive access to the WISE web-based educational intervention to help BCS
manage their symptoms, identify ergonomic workplace problems and risks, and implement
ergonomic modifications. Patients also receive standard of care comprising symptom
management therapies and a pamphlet on employment rights.

ARM II: Patients receive standard of care comprising symptom management therapies and a
pamphlet on employment rights.

After completion of study treatment, patients are followed up at 3 and 6 months.

Inclusion Criteria:

- Diagnosed with breast cancer

- Employed at time of cancer diagnosis (defined as paid employment > 20 hours/week)

- Within six months of completion of active treatment

- Working during treatment or intending to return to work following active treatment

- Computer and internet access

Exclusion Criteria:

- Patients who do not intend to continue/resume working following treatment

- Develop distant metastases or progressive disease

- Prior diagnosis of malignancy at any other site except for in situ carcinomas of the
cervix or non-melanomatous skin cancers

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Outcome Measure:

Usability of the WISE website as assessed by responses to a 5-point Likert scale

Outcome Description:

The primary analysis of the effect of the WISE intervention on work ability will be performed using a Wilcoxon rank sum test.

Outcome Time Frame:

3 months

Safety Issue:


Principal Investigator

Mary Sesto

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Wisconsin, Madison


United States: Institutional Review Board

Study ID:




Start Date:

April 2013

Completion Date:

Related Keywords:

  • Breast Cancer
  • Cancer Survivor
  • Breast Neoplasms



University of Wisconsin Hospital and ClinicsMadison, Wisconsin  53792-0001