Inclusion Criteria:

- ≥18 years

- Intrahepatic CCC, proven by histology or by typical morphology in cross sectional
imaging and elevated tumor markers (CEA or CA 19-9)

- Tumor confined to the liver

- At least one measurable lesion in magnetic resonance imaging (MRI)

- Tumor load ≤ 50%

- Preserved liver function (Child Pugh A and B)

- ECOG performance status ≤2

Exclusion Criteria:

- Patients feasible for curative treatment (e.g. resection or local ablation)

- Previous TACE or SIRT

- Chemotherapy during the last 4 weeks

- Child Pugh stage C

- ECOG Performance Status >2

- Tumor involvement >50% of the liver

- Extrahepatic tumor

- Serum Bilirubin >2.0 mg/dl; Serum Albumin 2.8 g/dl, Serum Creatinine >2 mg/dl;
Leukocytes <3000/ml; Thrombocytes <50000/ml

- Clinically apparent ascites (ascites only in CT/MRI is no exclusion criteria)

- Esophageal bleeding during the last 3 months

- Hepatic encephalopathy

- Transjugular intrahepatic portosystemic shunt (TIPS)

- Infiltration or occlusion of the main portal vein

- Hepatofugal blood flow in the portal vein

- Hepatopulmonary shunt ≥ 20% in the macroaggregated albumin scan (MAA-scan)

- Contraindications against angiography

- Gravidity