Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Change in COX-2 dependent urinary PGE-M (ng/mg Cr) production after 16 days of aspirin treatment
Baseline urinary PGE-2 metabolite (PGE-M) will be measured. Then after 3 days of COX-2 blockade with celecoxib, it will again be measured. Participants will then undergo 10 days of treatment with aspirin and urinary PGE-M will be measured. Finally, participants will be treated with combined aspirin and celecoxib for 3 days and urinary PGE-M will be measured one last time. Using these values, the degree of aspirin inhibition of COX-2 specific urinary PGE-M production can be calculated.
John A Oates, MD
United States: Institutional Review Board
|Vanderbilt University||Nashville, Tennessee 37232-6305|