Inclusion Criteria

Inclusion criteria

- Female or male aged 25 years or older.

- Mandatory provision of archival or fresh tumour biopsy for confirmation of FGFR gene
amplification.

- World Health Organisation performance status 0-2, minimum life expectancy of 12 weeks
from proposed first dose date

- Patient ability to comply with the collection of tumor biopsies which is mandatory at
baseline and on days 10-14

- Calcium and phosphate within normal limits.

- At least one lesion, not previously irradiated, that can be accurately measured at
baseline as >=10 mm in the longest diameter - except lymph nodes which must have
short axis >=15 mm.

- Local disease confined to the stomach or oesophagus is not considered measurable
(patients with locally advanced gastro-oesophageal adenocarcinoma must have at least
one measurable nodal lesion >=15mm in the short axis).

Tumour specific inclusion criteria

Advanced gastro-oesophageal adenocarcinoma

- Histologically proven metastatic or locally advanced inoperable adenocarcinoma of the
stomach, lower oesophagus or oesophago-gastric junction.

- Documented progression after 1 or 2 prior courses of chemotherapy for advanced
disease,

- FGFR2 amplification

Advanced breast carcinoma

- Histologically confirmed metastatic or locally advanced breast cancer, negative for
HER2 as determined by local laboratory.

- Patients with locally advanced disease must have recurrent, or progressive, disease
that is not suitable for treatment with curative intent

- Patients with ER positive disease must have been treated with at least one line of
hormonal therapy for recurrent/progressive disease or have been on hormonal therapy
at the time of recurrence/progression

- Documented progression after at least one and no more than three prior courses of
chemotherapy for advanced disease.

- FGFR1 amplification

Advanced squamous cell lung cancer

- Histologically confirmed metastatic or locally advanced squamous cell carcinoma of
lung

- Documented progression after 1 or 2 prior courses of chemotherapy for advanced
disease

- FGFR1 amplification

Exclusion criteria

- Treatment potent inhibitors or inducers of CYP3A4, 2C8 or 2D6 or substrates of CYP3A4
within specified durations prior to the first dose of study treatment

- Major surgery (excluding placement of vascular access) within 4 weeks before the
first dose of study treatment

- Radiotherapy with a wide field of radiation within 4 weeks or radiotherapy with a
limited field of radiation for palliation within 2 weeks before the first dose of
study treatment

- Prior exposure to AZD4547 or any other drug with FGFR inhibition as its primary mode
of action

- Untreated brain metastases

- Inadequate bone marrow reserve or organ function

- Corrected total calcium > ULN

- Total phosphate > ULN

- Mean resting corrected QT interval > 470 msec obtained from 3 consecutive
electrocardiograms (ECGs)

- Any of the following ophthalmological criteria: 1)Current evidence or previous
history of retinal pigmented epithelium detachment (RPED). 2)Previous laser treatment
or intra-ocular injection for treatment of macular degeneration. 3) Current evidence
or previous history of dry or wet age-related macular degeneration. 4) Current
evidence or previous history of retinal vein occlusion (RVO). 5) Current evidence or
previous history of retinal degenerative diseases (e.g. hereditary). 6) Current
evidence or previous history of any other clinically relevant chorioretinal defect