Benefits of Resistance Exercise Training in Locally Advanced Head and Neck Cancer Patients Undergoing Organ-Preserving Definitive Therapy
Patients with locally advanced head and neck cancer are treated with radiation therapy
(with/without chemotherapy) to avoid large surgical procedures. However, definitive
radiation treatments can cause side effects (like mouth sores, difficulty swallowing) that
often cause weight loss. It has been shown that a significant percentage of the weight loss
is due to loss of muscle mass. Resistance exercise training works to increase muscle
strength and endurance by doing repetitive exercises with weights, weight machines, or
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
The effect of resistance exercise training (RET) versus usual care (UC) on the preservation of lean body mass.
Lean body mass will be analyzed at baseline, 3, 5, and 7-weeks (representing the last week of cancer treatment and end of on-site RET), 11-weeks (first clinic follow-up) and 14-weeks (second clinic follow-up and end of home-based RET program) for patients on both arms of the study.
Shruti Jolly, MD
University of Michigan Cancer Center
United States: Institutional Review Board
|The University of Michigan Comprehensive Cancer Center||Ann Arbor, Michigan 48109|