Inclusion Criteria

- INCLUSION CRITERIA:

- Patients must have histologically-documented (confirmed at the Laboratory of
Pathology, NCI), solid tumor malignancy, or Hodgkin's disease/non-Hodgkin lymphoma,
that is metastatic or unresectable and for which standard curative measures do not
exist or are associated with minimal patient survival benefit.

- The Eastern Cooperative Oncology Group (ECOG) performance status less than or equal
to 2

- Life expectancy > 3 months.

- Patients must have normal or adequate organ and marrow function as defined below:

- Leukocytes greater than or equal to 3,000/mcL

- Absolute neutrophil count greater than or equal to 1,500/microL

- Platelets greater than or equal to 100,000/microL

- Total bilirubin less than or equal to 2.0 x institutional upper limit of normal
(we will allow patients with Gilbert's syndrome with total bilirubin up to 2.5
mg/dL)

- AST (SGOT)/ALT (SGPT) less than or equal to 3 x institutional upper limit of
normal

---patients with metastatic disease in the liver less than or equal to 5 x ULN

- Creatinine < 1.5 x upper limit of normal

- OR

- Creatinine clearance

- greater than or equal to 60 mL/minute for patients with creatinine levels

- greater than or equal to 1.5 x institutional upper limit of normal

- Age greater than or equal to 18

- The effects of indenoisoquinolines on the developing human fetus are unknown. For
this reason, women of child-bearing potential and men must agree to use adequate
contraception (hormonal or barrier method of birth control; abstinence) prior to
study entry, for the duration of study participation, and for 3 months after
completion of indenoisoquinolines administration. Should a woman become pregnant or
suspect she is pregnant while she or her partner is participating in this study, she
should inform her treating physician immediately. Men treated or enrolled on this
protocol must also agree to use adequate contraception prior to the study, for the
duration of study participation, and 3 months after completion of indenoisoquinolines
administration

- Ability to understand and the willingness to sign a written informed consent
document.

EXCLUSION CRITERIA:

- Patients must have recovered to at least eligibility levels due to adverse events
(AEs) and/or toxicity of prior chemotherapy or biologic therapy. They must not have
had major surgery, chemotherapy, radiotherapy, or biologic therapy within 3 weeks (6
weeks for nitrosoureas and mitomycin C, or 2 months for UCN-01). Patients must be
greater than or equal to2 weeks since any investigational agent administered as part
of a Phase 0 study (also referred to as an early Phase I study or pre-Phase I
study where a subtherapeutic dose of drug is administered) at the PI's discretion,
and should have recovered to eligibility levels from any toxicities. However,
patients receiving bisphosphonates for any cancer or undergoing androgen deprivation
therapy for prostate cancer are eligible for this therapy. Prior therapy with
topoisomerase I inhibitors is allowed.

- Patients who are receiving any other investigational agents.

- Patients with known active brain metastases are excluded from this clinical trial
because of their poor prognosis and because they often develop progressive neurologic
dysfunction that would confound the evaluation of neurologic and other adverse
events. Patients with brain metastasis stable for at least 4 weeks following surgery
and/or radiation are eligible.

- Uncontrolled incurrent illness including, but not limited to, symptomatic congestive
heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric
illness/social situations that would limit compliance with study requirements.

- HIV-positive patients on combination antiretroviral therapy are ineligible because of
the potential for pharmacokinetic interactions with LMP400. Appropriate studies will
be undertaken in patients receiving combination antiretroviral therapy when
indicated.

INCLUSION OF WOMEN AND MINORITIES:

- Both men and women of all races and ethnic groups are eligible for this trial.