Longitudinal Assessment of Ovarian Reserve in Adolescents With Lymphoma
The primary objectives of this study are to compare Anti Mullerian Hormone (AMH), Follicle
Stimulating Hormone (FSH), and Estradiol (E2) between patients (enrolled groupwide) at two
timepoints (baseline and 12 months off therapy) and a cross section of controls (enrolled at
limited institutions) and to describe the trajectory of AMH, FSH, and E2 from baseline to 12
months after completion of gonadotoxic cancer treatment.
Observational Model: Cohort, Time Perspective: Prospective
Comparison of the measures of ovarian reserve (AMH, FSH and E2) to that of healthy controls
Compared using the Wilcoxon rank-sum test or the two sample t-test after appropriate transformation. Analysis of covariance will be used to adjust these comparisons for covariates including age, race, dose of alkylating agent and use of hormone medications.
12 months post therapy
Jennifer M Levine, MD, MSW
United States: Institutional Review Board