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Peripheral Blood DNA Methylation Markers for the Early Detection of Colorectal Carcinoma in the Egyptian Population


N/A
18 Years
85 Years
Open (Enrolling)
Both
Colorectal Neoplasms, Adenoma, Colorectal Tumors

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Trial Information

Peripheral Blood DNA Methylation Markers for the Early Detection of Colorectal Carcinoma in the Egyptian Population


Inclusion Criteria:



- Patients undergoing colonoscopy as part of their clinical care or part of screening
program.

- Complete endoscopic examination (up to the caecum)

- Adequate colonic preparation

Exclusion Criteria:

- - Incomplete colonoscopic examination due to technical causes e.g. difficult
colonoscopy, patient intolerance (N.B. a neoplastic mass causing lumen stenosis will
not be excluded.)

- Poor colonic preparation obscuring adequate mucosal examination.

- Patients who have received any treatment for CRC and/or adenomas.

- Patients with known malignancy elsewhere (i.e. non-colorectal malignancy)

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Methylation markers present in peripheral blood of patients with colorectal cancer(Sept 9, CDKN2B-p15, CDH4, SFRP2, ALX4, Neurog1 and CDH13)in comparison to their presence in other subjects

Outcome Time Frame:

16 months

Safety Issue:

No

Principal Investigator

Hany M Shehab, MD, MRCP

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cairo University

Authority:

Egypt: Science and Technological Development Fund

Study ID:

CRCS001

NCT ID:

NCT01793207

Start Date:

December 2012

Completion Date:

March 2014

Related Keywords:

  • Colorectal Neoplasms
  • Adenoma
  • Colorectal Tumors
  • Adenoma
  • Neoplasms
  • Carcinoma
  • Colorectal Neoplasms

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