Clomiphene Citrate Plus HPuFSH Versus Letrozole Plus HPuFSH in Clomid Resistant Infertile PCOS Women
18 Years
38 Years
Female
Polycystic Ovary Syndrome, Infertility
Trial Information
Clomiphene Citrate Plus HPuFSH Versus Letrozole Plus HPuFSH in Clomid Resistant Infertile PCOS Women
To test whether CC co- treatment with chronic low dose HP uFSH versus lirizole plus chronic
low dose HP uFSH in CC resistant PCOS will yield comparable results in terms of, ovulation
rate, lower follicle number, lower HP uFSH dose, better outcome in terms of pregnancy rates,
better cost-effectiveness ratio, lower multiple pregnancy rates, lower cycle cancellation.
Inclusion Criteria:
- CC resistant PCOS
- Infertile
- Females
- Age 18-38
Exclusion Criteria:
- Hyperprolactinaemia
- Cushing syndrome
- Adult onset adrenal hyperplasia
- Age > 38
- Other infertility factors in the couple than PCOS: male factor,tubal
factor,edometriosis
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
ovulation rate
Outcome Description:
percentage of ovulatory cycles per started and per completed cycles
Outcome Time Frame:
30 days
Safety Issue:
No
Authority:
Egypt: Institutional Review Board
Study ID:
Mific-3
NCT ID:
NCT01793038
Start Date:
March 2013
Completion Date:
September 2014
Related Keywords:
- Polycystic Ovary Syndrome
- Infertility
- PCOS
- clomiphene citrate resistant PCOS
- Aromatase inhibitors
- Infertility
- Polycystic Ovary Syndrome
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