The Role of an Optical Probe in the Detection of Thyroid Cancer and Normal Thyroid Tissue in a Thyroidectomy Specimen: A Pilot Study
N/A
N/A
Both
Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer
Trial Information
The Role of an Optical Probe in the Detection of Thyroid Cancer and Normal Thyroid Tissue in a Thyroidectomy Specimen: A Pilot Study
The optical real-time readings will be compared to the histological analysis from the same
area. Subjects undergoing thyroid surgery for thyroid disease including thyroid nodules,
thyroid cancer and thyroid goiter with nodules will be eligible to participate. After the
removal of the thyroid gland, optical readings will be taken from the ex vivo thyroid gland
and these same areas will then be analyzed in the usual standard fashion. The reading will
then be correlated with the histological results. In addition, if lymph nodes are removed as
part of the surgery they will also be tested prior to histological standard processing. All
specimens and data will be de-identified.
Inclusion Criteria:
- Subjects undergoing thyroid surgery for thyroid nodules, thyroid cancer, and thyroid
goiter with nodules.
Exclusion Criteria:
- Subjects whose thyroid specimens have been put in formalin
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
Assess optical probe for the differentiation of thyroid cancer from normal thyroid tissue and benign thyroid nodules
Outcome Description:
The objective is to assess a device called an optical probe for the differentiation of thyroid cancer from normal thyroid tissue, benign thyroid nodules or parathyroid glands, and the detection of thyroid cancer within lymph nodes using a hand-held spectroscope, compare the spectra from benign and malignant thyroid nodules and use this to discriminate benign from malignant nodules based on final histopathology or cytology as the gold standard.
Outcome Time Frame:
two years
Safety Issue:
No
Principal Investigator
Jennifer E Rosen, M.D. FACS
Investigator Role:
Principal Investigator
Investigator Affiliation:
Boston Medical Center
Authority:
United States: Institutional Review Board
Study ID:
H28135
NCT ID:
NCT01792492
Start Date:
June 2009
Completion Date:
November 2013
Related Keywords:
- Thyroid Nodule
- Thyroid Neoplasms
- Thyroid Cancer
- Thyroid Neoplasms
- Optical Devices
- Spectrum Analysis
- Thyroid diseases
- Neoplasms
- Thyroid Neoplasms
- Thyroid Diseases
- Thyroid Nodule
Name | Location |
|---|---|
| Boston Medical Center | Boston, Massachusetts 02118 |
