Inclusion Criteria:

- Age ≥ 18 years

- Body mass index ≥ 25 kg/m2

- Glycosylated hemoglobin (A1C) value ≥ 6.5% OR having a fasting blood glucose ≥ 126
mg/dL

- On stable antiretroviral therapy for ≥ 12 months (with a fully suppressed plasma
HIV-1 RNA level)

- Negative serum pregnancy test (females only)

Exclusion Criteria:

- History of pancreatitis

- Screening serum lipase value greater than or equal to 2 times the upper limit of
normal (≥ 420 U/L)

- History of pancreatic cancer or thyroid cancer in patient, a first-degree relative,
or a grandparent

- History of Multiple Endocrine Neoplasia (MEN) 2 syndrome

- History of gastroparesis, inflammatory bowel disease, and/or other severe
gastrointestinal disease

- Estimated glomerular filtration rate (eGFR) ≤ 50 mls/minute

- Documented history of hypoglycemia (blood glucose <40 mg/dl)

- Active moderate-heavy alcohol use (more than 2 drinks/day) or >4 drinks in a single
24 hour period

- On an anti-diabetic medication within 3 months of enrollment

- On an HMG-CoA reductase inhibitor (statin) within 3 months of enrollment

- Persons on a didanosine (ddI) and/or stavudine (d4T)-containing cART (due to the
heightened risk of pancreatitis)