Feasibility of an Evidence-based Walking Program in a Sample of Cancer Patients >60 Years of Age Undergoing Cytotoxic Chemotherapy
The primary purpose of this study is to evaluate the feasibility of implementing a
moderate-intensity walking program (Walk With Ease/WWE) among cancer patients, age ≥60
years, as they undergo cytotoxic chemotherapy treatment. Feasibility will be determined
based on the rate of participation in the WWE program. As secondary objectives, we will also
establish the rate of completion of a number of instruments, including a Geriatric
Assessment tool, and other instruments that measure self-reported quality of life (e.g.,
fatigue, depression, and pain), and self-reported physical activity (PA). Data from these
instruments, as well as from serial measurements of a biomarker of aging (p16INK4a) will be
explored and used to inform future studies designed to evaluate any relationship between
these variables and participation in the WWE program.
We propose a sample (n=30) of cancer patients ≥60 years of age with potentially curable
cancer and a diagnosis of Stage I-III breast cancer, Stage I-III lung cancer, or Stage
II-III colon cancer, who are about to begin chemotherapy. Participation will be defined as
completing the 6-week WWE program. Results from this study will be used in an RO1
application to the National Cancer Institute (NCI) pertaining to PA interventions among
cancer patients and the effects of biomarkers on prognosis and survival.
Observational Model: Cohort, Time Perspective: Prospective
To measure the feasibility of implementing the WWE program among cancer patients, age ≥60, as they undergo cytotoxic chemotherapy treatment.
Feasibility will be defined as the proportion of recruited subjects who complete the 6-week WWE program.
Hyman Muss, MD
University of North Carolina Lineberger Comprehensive Cancer Center
United States: Institutional Review Board
|University of North Carolina Cancer Hospital||Chapell Hill, North Carolina 27514|