The Impact of Activated p-AKT Expression on Clinical Outcomes in Malignant Lymphoma : A Clinicopathological Study
Recently, among diverse oncogenic signaling pathways, a number of studies have focused on
the significance of oncogenic PI3K/AKT (phophatidylinositol 3-kinase/serine-threonine
kinase, also known as protein kinase B [PKB]) pathway. PI3K(phosphatidylinositol
3-kinase)/AKT pathway phosphorylates and activates AKT as phosphorylated AKT (p-AKT) and
plays a critical role promoting malignant phenotype and has prognostic significance in
various solid cancers.
However, a systematic approach on the impact of p-AKT overexpression on clinical outcomes
has not been performed in malignant lymphoma.
Observational Model: Cohort, Time Perspective: Retrospective
Difference of overall survival according to p-AKT status in malignant lymphoma
Won Seog Kim, MD PhD
Samsung Medical Center
South Korea: Institutional Review Board