Inclusion Criteria:

1. Patients undergoing hematopoietic stem cell transplantation conditioned with highly
or moderately emetogenic drugs or total body irradiation (TBI) for hematologic
malignancies

2. aged over 18 yrs

3. Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2

4. patients who are able to take oral medications

5. patients who get well-informed and sign the consent

Exclusion Criteria:

1. Patients complicating

- severe hypertension (systolic blood pressure > 210 mmHg or diastolic blood
pressure > 120 mmHg)

- significant heart disease such as congestive heart failure

- renal insufficiency (serum Cr >= 3.0 mg/dL)

- liver disease (Aspartate aminotransferase (AST), alanine aminotransferase (ALT)
> 3 upper normal limit; alkaline phosphatase (ALP) > 2 upper normal limit)

2. Patients complicated by conditions such as gastrointestinal obstruction or active
peptic ulcer causing emesis

3. Patients with brain tumor, brain metastasis and epilepsy

4. Patients with the history of extrapyramidal symptom

5. Patients with the history of allergy to serotonin antagonists

6. pregnant or lactating women

7. Patients with drug abuse or psychiatric illness, or patients who are not capable of
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