Treatment With Danazol Before Controlled Ovarian Hyperstimulation in Women With Endometriosis Undergoing IVF
18 Years
40 Years
Female
Endometriosis, Ovarian Cysts, Infertility
Trial Information
Treatment With Danazol Before Controlled Ovarian Hyperstimulation in Women With Endometriosis Undergoing IVF
Endometriosis is a chronic benign disease defined by the presence of endometrial tissue
outside the uterine cavity, affecting women in their reproductive age. This disease is
clinically characterized by infertility pelvic pain and the presence of ovarian cysts,
endometriomas, and affects the about 10% of women. Women with endometriosis when undergo IVF
show lower pregnancy rate than general population, and a reduced ovarian reserve, due to the
diseases and often to ovarian surgery. The aim of this study is to evaluate if a
pre-treatment with danazol, an anti-estrogenic agent, may improve the otcome of IVF cycles
in these women
Inclusion Criteria:
- Clinical diagnosis of endometriosis previous laparoscopic surgery for ovarian
endometriotic cysts infertility
Exclusion Criteria:
- age more than 40 years systemic disease antimulleran hormone (AMH)<1 and FSH>20
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Outcome Measure:
pregnancy rate
Outcome Description:
number of ongoing pregnancy for the number of IVF cycles
Outcome Time Frame:
12 months
Safety Issue:
Yes
Principal Investigator
Marco Sbracia, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Centre for Endocrinology and Reproductive Medicine, Italy
Authority:
Italy: National Monitoring Centre for Clinical Trials - Ministry of Health
Study ID:
CR-09-2013
NCT ID:
NCT01779232
Start Date:
October 2012
Completion Date:
December 2013
Related Keywords:
- Endometriosis
- Ovarian Cysts
- Infertility
- endometriosis
- ivf
- ovarian reserve
- danazol
- Endometriosis
- Infertility
- Ovarian Cysts
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