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Arginine and Nitric Oxide (NO) Metabolism in Healthy Human Volunteers


N/A
18 Years
70 Years
Not Enrolling
Both
Healthy

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Trial Information

Arginine and Nitric Oxide (NO) Metabolism in Healthy Human Volunteers


Inclusion Criteria:



- Written informed consent

- Age 18-25 years (young); 50-70 years (middle aged/elderly)

Exclusion Criteria:

- Diabetes mellitus type I

- Livercirrhosis, pancreatitis, malignancies

- Hypertension (diastolic blood pressure >95 mmHg or systolic blood pressure >160 mmHg)

- History of gastrointestinal complaints

- Recent involuntary weight loss (more than 10 % in 6 months or more than 5 % in one
month)

- Pregnancy (pregnancy test is done in female subjects)

- Use of medication that can affect arginine metabolism (nitrovasodilators and
corticosteroids)

- Subjects with "high activity level"

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Primary Purpose: Basic Science

Outcome Measure:

whole body NO synthesis

Outcome Description:

postabsorptive nitric oxide synthesis measured by using stable isotope methodology

Outcome Time Frame:

2 hours

Safety Issue:

No

Principal Investigator

Nicolaas E Deutz, MD PhD

Investigator Role:

Principal Investigator

Authority:

Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:

MEC04-021.3

NCT ID:

NCT01774994

Start Date:

November 2004

Completion Date:

June 2012

Related Keywords:

  • Healthy
  • volunteers

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