Molecular Epidemiology of Lung Adenocarcinoma in Multi-ethnic Asian Phenotype
Lung cancer is a malignant disease of heterogeneous histology and is divided into 2 major
groups; small cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC accounts for
75% of lung cancers, and can exhibit different pathways of resistance during treatment. It
is increasingly apparent that effective treatment of NSCLC will require multiple drugs that
attack different targets. This realization sets the stage for future individualized
therapies that will depend on the molecular characteristics of NSCLC to target various
1. Describe the molecular epidemiology of lung adenocarcinoma in multi-ethnic asian
2. Correlate tumor molecular characteristics with patient demographics and outcome to
better understand carcinogenesis as well as in the discovery of novel targets for
future drug development.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Descriptive study of our patients with lung adenocarcinoma. Identify novel molecular characteristics so that potential drug development can be reached.
Pyng Lee, MD
National University Hospital, Singapore
Singapore: Domain Specific Review Boards