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Molecular Epidemiology of Lung Adenocarcinoma in Multi-ethnic Asian Phenotype

21 Years
Open (Enrolling)
Lung Cancer

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Trial Information

Molecular Epidemiology of Lung Adenocarcinoma in Multi-ethnic Asian Phenotype

Lung cancer is a malignant disease of heterogeneous histology and is divided into 2 major
groups; small cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC accounts for
75% of lung cancers, and can exhibit different pathways of resistance during treatment. It
is increasingly apparent that effective treatment of NSCLC will require multiple drugs that
attack different targets. This realization sets the stage for future individualized
therapies that will depend on the molecular characteristics of NSCLC to target various


1. Describe the molecular epidemiology of lung adenocarcinoma in multi-ethnic asian

2. Correlate tumor molecular characteristics with patient demographics and outcome to
better understand carcinogenesis as well as in the discovery of novel targets for
future drug development.

Inclusion Criteria:

- Asian ethnicity

- Age > 21 years old

- Non-smoker

- Metastatic pleural effusion due to lung adenocarcinoma

- Good ECOG status (ECOG 1-2) fit to undergo pleuroscopy and biopsy and agreeable for
palliative chemotherapy and or EGFR-TKI

Exclusion Criteria:

- Non-Asian ethnicity

- Age < 21 years old

- Smoker

- Subjects with poor ECOG status or unwilling to undergo pleuroscopy and biopsy

- Subjects not suitable to receive palliative chemotherapy or EGFR-TKI

- All other histological subtypes and stages of disease

Type of Study:


Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Descriptive study of our patients with lung adenocarcinoma. Identify novel molecular characteristics so that potential drug development can be reached.

Outcome Time Frame:

6 years

Safety Issue:


Principal Investigator

Pyng Lee, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

National University Hospital, Singapore


Singapore: Domain Specific Review Boards

Study ID:




Start Date:

December 2010

Completion Date:

December 2016

Related Keywords:

  • Lung Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Lung Neoplasms