Inclusion Criteria:

- Adult patient, >/= 18 years of age

- HER2-positive breast cancer

- Histologically confirmed invasive breast carcinoma

- Clinical stage T1-4/N0-3/M0 at presentation (patients with T1a/bN0 tumors will not be
eligible)

- Completion of preoperative systemic treatment consisting of at least 6 cycles with a
total duration of at least 16 weeks, including at least 9 weeks of trastuzumab and at
least 9 weeks of taxane-based therapy

- Adequate excision: surgical removal of all clinically evident disease in the breast
and lymph nodes as specified in protocol

- Pathological evidence of residual invasive carcinoma in the breast or axillary lymph
nodes following completion of preoperative therapy

- An interval of no more than 12 weeks between the date of surgery and the date of
randomization

- Known hormone-receptor status

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Adequate hematologic, renal and liver function

- Left ventricular ejection fraction (LVEF) >/= 50% at screening and no decrease in
LVEF by more than 15% absolute points from pre-chemotherapy

- Women of childbearing potential and men with partners of childbearing potential must
be willing to use effective contraception as defined by protocol for the duration of
study treatment and for at least 6 months after the last dose of study treatment

- Documentation of hepatitis B virus and hepatitis C virus serology is required

Exclusion Criteria:

- Stage IV (metastatic) breast cancer

- History of any prior (ipsi- or contralateral breast cancer except lobular carcinoma
in situ

- Evidence of clinically evident gross residual or recurrent disease following
preoperative therapy and surgery

- Progressive disease during preoperative therapy

- Treatment with any anti-cancer investigational drug within 28 days prior to
commencing study treatment

- History of other malignancy within the last 5 years except for appropriately treated
carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage I uterine cancer,
or other non-breast malignancies with a similar outcome to those mentioned above

- Patients for whom radiotherapy would be recommended for breast cancer treatment but
for whom it is contraindicated because of medical reasons

- Current NCI CTCAE (Version 4.0) Grade >/= 2 peripheral neuropathy

- History of exposure to the following cumulative doses of anthracyclines:

Doxorubicin > 240 mg/m2 Epirubicin > 480 mg/m2 For other anthracyclines, exposure
equivalent to doxorubicin > 240 mg/m2

- Cardiopulmonary dysfunction as defined by protocol

- Prior treatment with trastuzumab emtansine

- Current severe, uncontrolled systemic disease

- Pregnant or lactating women

- Any known active liver disease, e.g. due to HBV, HCV, autoimmune hepatic disorders,
or sclerosing cholangitis

- Concurrent serious uncontrolled infections or known infection with HIV

- History of intolerance, including Grade 3 to 4 infusion reaction or hypersensitivity
to trastuzumab or murine proteins