Inclusion Criteria:

- Age: ≥ 18 and ≤ 75 years, both male and female;

- Radical hepatectomy has been performed for hepatocellular carcinoma;

- The hepatocellular carcinoma has been confirmed by pathological examination;

- Barcelona clinic liver cancer(BCLC) stage A or B;

- Not receiving any preoperative anticancer drug;

- The liver and kidney function satisfies the following conditions within 15 days after
surgery (excluding day 15): aspartate aminotransferase(AST), glutamic-oxalacetic
transaminase(ALT)<3 upper limit of normal(ULN), total bilirubin≤2ULN, serum
creatinine <1.5 ULN;

- Other laboratory tests meet the following requirements within 15 days after surgery
(excluding day 15): Hb≥9g/dl, platelet count≥60×109/L, absolute neutrophil
count>1.0×109/L;

- The expected survival time ≥ 12 weeks;

- The subjects volunteer to sign the informed consent.

Exclusion Criteria:

- Hepatocellular carcinoma patients who received non-radical hepatectomy;

- Non-hepatocellular carcinoma patients;

- Those with Child-Pugh C;

- Pregnant or lactating women;

- Those with active bleeding due to various reasons;

- Those with HIV infection or AIDS-associated diseases;

- Those with severe acute and chronic diseases;

- Those with severe diabetes;

- Those with serious infectious diseases;

- Those who can not take drugs by oral route;

- Drug abusers or those with psychological or mental diseases that may interfere with
study compliance;

- Conditions that are considered not suitable for this study investigators