Predicting Clinical Response and Outcome After Definitive Irradiation With MRI-Guided Adaptive Brachytherapy in Uterine Cervix Cancer
This study will prospectively collect patients undergoing to the standard diagnostic and
treatment protocol in Maastro Clinic. Any difference in the normal procedure will be
adopted. The aim is to extrapolate form the PET images some features of the metabolic tumor
activity to associate with different outcomes and tumor behaviours.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Change of SUV-related tumor characteristics predicting recurrence
Standard Uptake Value Max (SUV- defined as the ratio of tissue radioactivity concentration (e.g. in MBq/kg=kBq/g) at time t, c(t), and the injected activity ( in MBq) at the time of injection (t=0) divided by the body weight in kg), Metabolic Volume (MV) calculated in cc:volume of the evaluable metabolic activity on the PET scan calculated in a specific Region of Interest (ROI) semiautomatically delineated on the primary tumor in the uterine Cervix
Changes of parameters will be calculated on the pretreatment scan, than in average 2.5 months after the last radiotherapy session, than at least each 6 month for the first 2 years, eventually shortening the interval if clinically needed
No
philippe Lambin
Principal Investigator
MAASTRO Clinic
Netherlands: Medical Ethics Review Committee (METC)
CERVMA01
NCT01764217
July 2006
January 2013
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