Inclusion Criteria:

- Squamous Non-Small Cell Lung Cancer Disease

- Clinical Stage IV

- Measurable or nonmeasurable disease as defined by Response Evaluation Criteria in
Solid Tumors (RECIST) version 1.1

- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1

- No prior chemotherapy regimen, surgery and chest radiotherapy

- Adequate organ function

- Estimated life expectancy of at least 12 weeks

Exclusion Criteria:

- Has undergone major surgery within 28 days prior to enrollment or have planned major
surgery, subcutaneous venous access device placement within 7 days prior to
enrollment

- Has undergone any prior radiation therapy, except for Gamma Knife radiation and
palliative radiation treatment at least 14 days have elapsed from last radiation
treatment prior to enrollment

- Has brain metastases that are symptomatic or require surgery, medication and
radiotherapy except Gamma Knife

- Has superior vena cava syndrome

- Has clinically relevant coronary artery disease or uncontrolled congestive - heart
failure

- Has uncontrolled hypertension

- Has diabetes requiring insulin

- Has an angina or has experienced myocardial infarction within 6 months prior to
enrollment

- Has an Acquired Immunodeficiency Syndrome (AIDS)-related illness

- Has evidence of or test positive test results for hepatitis B, or hepatitis C virus
antibodies

- Has a known allergy and history of hypersensitivity reaction

- Has significant third-space fluid retention

- Has history of interstitial pneumonitis

- Has an ongoing or active infection

- Has a history of significant neurological or psychiatric disorders

- Has a Grade 2 peripheral neuropathy