Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding (AUB) Using Sublingual Misoprostol 200 Mcg: A Randomized, Double Blind, Placebo-controlled Trial
35 Years
N/A
Female
Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
Trial Information
Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding (AUB) Using Sublingual Misoprostol 200 Mcg: A Randomized, Double Blind, Placebo-controlled Trial
Inclusion Criteria:
- thai women at the age over 35 years old
- presenting with abnormal uterine bleeding and have a plan to perform fractional
curettage
Exclusion Criteria:
- uterine anomalies
- pregnancy
- pelvic inflammatory disease
- uncontrolled medical or psychological conditions
- known cases of gynecological diseases such as gynecological malignancies, abnormal
pap smear
- Prostaglandin allergy
- Contraindicate to prostaglandin: asthma, mitral valve stenosis, glaucoma, sickle cell
anemia
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
Outcome Measure:
efficacy of 200 microgram Misoprostol for cervical ripening prior to performing fractional curettage in patients with abnormal uterine bleeding
Outcome Description:
an efficacy of sublingual misoprostol in this study was dilatation of uterine cervix which was measured by a diameter of MVA cannula in millimeters.
Outcome Time Frame:
1 Year
Safety Issue:
No
Principal Investigator
Korakot Sirimai, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Mahidol University
Authority:
Thailand: Ethical Committee
Study ID:
SIOGMVA002
NCT ID:
NCT01762319
Start Date:
November 2012
Completion Date:
June 2013
Related Keywords:
- Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
- Hemorrhage
- Metrorrhagia
- Uterine Hemorrhage
- Adenoma
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