Effect of Dexmedetomidine on Mortality, Duration of Mechanical Ventilation and Multi-organ Function in Sepsis Patients Under Lighter Sedation by Randomized Control Trial
Phase 4
20 Years
N/A
20 Years
N/A
Open (Enrolling)
Both
Sepsis
Both
Sepsis
Trial Information
Effect of Dexmedetomidine on Mortality, Duration of Mechanical Ventilation and Multi-organ Function in Sepsis Patients Under Lighter Sedation by Randomized Control Trial
Inclusion Criteria:
- adult
- transferred to ICU
- anticipation of a need for mechanical ventilation at least 24 hours
Exclusion Criteria:
- sever chronic liver disease (Child B or C)
- acute myocardial infarction, heart disease (NYHA 4)
- Drug dependence, alcoholism
- Psychological illness, severe cognitive dysfunction
- patients who have allergy for dexmedetomidine
- attending physician's decision
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
mortality
Outcome Description:
mortality of patients on 28 days or on a day of discharge if patients are discharged earlier than 28 days
Outcome Time Frame:
on 28 days
Safety Issue:
Yes
Principal Investigator
Yu Kawazoe
Investigator Role:
Study Chair
Investigator Affiliation:
Wakayama Medical University
Authority:
Japan: Ministry of Health, Labor and Welfare
Study ID:
DESIRE
NCT ID:
NCT01760967
Start Date:
January 2013
Completion Date:
Related Keywords:
- Sepsis
- Dexmedetomidine
- sepsis
- mortality
- duration of mechanical ventilation
- organ failure
- Sepsis
- Toxemia
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