Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring
I. Optimize and develop functional DCE-MRI pulse sequences, which involve the injection of
MRI-visible contrast agents, for imaging in the head/neck, abdominal and pelvic regions.
II. Determine the ideal radiofrequency (RF) coil setup to maximize signal to noise ratio of
the optimized pulse sequences.
III. Distill the findings of specific aims 1 and 2 into streamlined protocols that can be
used in subsequent studies for cancer phenotyping and treatment monitoring in a quantitative
IV. To establish a virtual reference image repository for future studies.
OUTLINE: Patients undergo DCE-MRI over approximately 30-60 minutes consisting of an
anatomical scout image to localize the region of interest, a set of pre-injection scans to
calibrate the dynamic image set, a dynamic image set during which contrast agent will be
injected, and a set of post-injection scans to calibrate the DCE-MRI database.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Dynamic contrast-enhanced MRI (DCE-MRI) as a measure of tumor treatment response.
Analysis of DCE-MRI data will be by semi-quantitative metrics such as the area under the curve (AUC), the slopes of contrast agent uptake and washout curves as well as peak contrast agent uptake. Alternatively quantitative metrics based upon pharmacokinetic modeling will be derived. The model is the 2-compartment Kety model from which volume transfer constants between compartments and volume of the tissue compartments can be calculated.
Jinha Park, MD, Ph.D.
City of Hope Medical Center
United States: Institutional Review Board
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