Inclusion Criteria:

- Women with histologically proven invasive breast cancer without distant metastases
and lymph node negative and a clinical tumor classification of T1cN0 or stage II-III

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- At least one lesion that can be accurately measured in two dimensions utilizing
mammogram, ultrasound, or magnetic resonance imaging (MRI) images to define specific
size and validate complete clinical and pathologic response

- Patients who received radiation therapy > 5 years ago for malignancies other than
breast cancer and whose radiation therapy field is not overlapping with the 20%
isodose line of current radiation field are eligible, provided that radiation therapy
was completed > 5 years ago and that there is no evidence of the second malignancy at
the time of study entry

- All malignant disease must be able to be encompassed within a single irradiation
field

- Absolute neutrophil count greater than or equal to 1,500/mcl

- Platelet count equal to or greater than 150,000/mcl

- Hemoglobin > 11gm/dl

- Alkaline phosphatase equal or less than 1.5 times the upper limit of normal (ULN)

- Total bilirubin equal to or less than 1.5 times the ULN

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) no greater than
1.5 times the ULN

- Creatinine less than 1.5 times the ULN

- All included patients must have normal cardiac function as defined by an ejection
fraction of > 50% and no decrease in wall motion by echocardiogram

- The patient must be aware of the neoplastic nature of his/her disease and willingly
provide written, informed consent after being informed of the procedure to be
followed, the experimental nature of the therapy, alternatives, potential benefits,
side-effects, risks, and discomforts

- Women of reproductive potential must be non-pregnant and non-nursing and must agree
to employ an effective barrier method of birth control throughout the study and for
up to 6 months following treatment

- Women of child-bearing potential must have a negative pregnancy test within 7 days of
initiating study; (no childbearing potential is defined as age 55 years or older and
no menses for two years or any age with surgical removal of the uterus and/or both
ovaries)

Exclusion Criteria:

- Any patient with inflammatory breast cancer or stage IV or confirmed metastatic
disease

- Patients who have had any prior chemotherapy, or endocrine therapy for the treatment
of breast cancer or any other cancer

- Patients who cannot undergo surgery

- Patients with a known or documented anaphylactic reaction or allergy to any of
chemotherapy agents used in this protocol, or to antiemetics appropriate for
administration in conjunction with protocol-directed therapy

- Uncontrolled inter-current illness including, but not limited to ongoing or active
infection requiring intravenous antibiotics, symptomatic congestive heart failure,
unstable angina pectoris, or serious, uncontrolled cardiac arrhythmia, that might
jeopardize the ability of the patient to receive the therapy program outlined in this
protocol with reasonable safety

- Patients with preexisting grade II peripheral neuropathy

- Pregnant and nursing women are excluded from this study because the chemotherapy
agents and radiation therapy all have the potential for teratogenic or abortifacient
effects

- Patients with prior malignancy will be excluded except for adequately treated basal
cell or squamous cell skin cancer, adequately treated noninvasive carcinomas

- Inability to cooperate with treatment protocol

- Patients with known human immunodeficiency virus (HIV) infection, infectious
hepatitis, type A, B or C, active hepatitis, or hepatic insufficiency

- Patients may not be receiving or have received any other investigational agents
during/or within 1 month prior

- Any serious medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from signing the informed consent form

- Myocardial infarction within 6 months prior to enrollment or has New York Heart
Association (NYHA) class III or IV heart failure uncontrolled angina, severe
uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute
ischemia or active conduction system abnormalities; prior to study entry, any
electrocardiogram (ECG) abnormality at screening has to be documented by the
investigator as not medically relevant