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Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Phase 2
20 Years
60 Years
Not Enrolling
Chronic Arsenic Poisoning

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Trial Information

Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and
soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition.
Till today there is no effective treatment.

Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated
with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be
given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of
this study is to examine the effectiveness of oral administration of garlic oil to reduce
body arsenic load and clinical symptoms of arsenical palmer keratosis.

Inclusion Criteria

Inclusion Criteria (Patients):

- history of taking arsenic contaminated water (>50 ppb) for more than 6 months

- patients having mild to moderate arsenical keratosis present on palm of the hand

- patients those voluntarily agree to participate

Inclusion Criteria (Arsenic exposed controls):

- family member of the patient

- drinking arsenic contaminated water from the same source as patient

- those voluntarily agree to participate

- no sign/symptom of palmer keratosis

Inclusion Criteria (Healthy volunteers):

- drinking arsenic safe water (<50 ppb)

- those voluntarily agree to participate

Exclusion Criteria:

- pregnancy

- lactating mother

- patient receiving treatment of arsenicosis

- any other chronic disease like tuberculosis, diabetes mellitus, bronchial asthma

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Change in the clinical symptom of keratosis in palm

Outcome Time Frame:

0 week (baseline) to 12 weeks (end)

Safety Issue:


Principal Investigator

Mir Misbahuddin, MBBS, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.


Bangladesh: Ethical Review Committee

Study ID:




Start Date:

October 2011

Completion Date:

July 2012

Related Keywords:

  • Chronic Arsenic Poisoning
  • Arsenic
  • Arsenicosis
  • Garlic oil
  • Keratosis
  • Keratosis
  • Keratosis, Actinic
  • Poisoning
  • Arsenic Poisoning