Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis
Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and
soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition.
Till today there is no effective treatment.
Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated
with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be
given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of
this study is to examine the effectiveness of oral administration of garlic oil to reduce
body arsenic load and clinical symptoms of arsenical palmer keratosis.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Change in the clinical symptom of keratosis in palm
0 week (baseline) to 12 weeks (end)
Mir Misbahuddin, MBBS, PhD
Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Bangladesh: Ethical Review Committee