Diagnostic Value of Whole-Body MRI Compared to FDG-PET-CT for Rectal Cancer Preoperative Staging, Before and After Neoadjuvant Treatment
Rectal cancer is the second cause of mortality after lung cancer in industrialized countries
and represent 28% of colorectal carcinomas. Despite major improvements in diagnosis and
treatment made those last years,mortality and morbidity remains high, because of high
prevalence of metastasis and local recurrence. A accurate initial staging is of paramount
importance for an appropriate treatment (neoadjuvant chemiotherapy and radiotherapy,
Actually, there is no international consensus concerning imaging for the staging of rectal
cancer and modalities used are variable from one center to another.
WB-MRI represented a attractive and promising technique for the staging of rectal cancer,
free of ionizing radiation .
Observational Model: Cohort, Time Perspective: Prospective
Evaluate the diagnostic accuracy of whole-body MRI for the staging of rectal cancer before and after neoadjuvant treatment
We will compare for each body region the findings of the whole-body MRI to the FDG-PET-CT considered as the gold-standard and measure sensibility/specificity and diagnostic accuracy of the whole-body MRI for distant lesions of rectal cancer.
baseline and 1 week before surgery
University of Lausanne Hospitals