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Diagnostic Value of Whole-Body MRI Compared to FDG-PET-CT for Rectal Cancer Preoperative Staging, Before and After Neoadjuvant Treatment


N/A
18 Years
95 Years
Open (Enrolling)
Both
Rectal Cancer

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Trial Information

Diagnostic Value of Whole-Body MRI Compared to FDG-PET-CT for Rectal Cancer Preoperative Staging, Before and After Neoadjuvant Treatment


Rectal cancer is the second cause of mortality after lung cancer in industrialized countries
and represent 28% of colorectal carcinomas. Despite major improvements in diagnosis and
treatment made those last years,mortality and morbidity remains high, because of high
prevalence of metastasis and local recurrence. A accurate initial staging is of paramount
importance for an appropriate treatment (neoadjuvant chemiotherapy and radiotherapy,
surgery).

Actually, there is no international consensus concerning imaging for the staging of rectal
cancer and modalities used are variable from one center to another.

WB-MRI represented a attractive and promising technique for the staging of rectal cancer,
free of ionizing radiation .


Inclusion Criteria:



- rectal cancer T3 N+ or T3 or T4

Exclusion Criteria:

- renal failure

- allergy to iodinated contrast medium

- contraindication to MRI

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Evaluate the diagnostic accuracy of whole-body MRI for the staging of rectal cancer before and after neoadjuvant treatment

Outcome Description:

We will compare for each body region the findings of the whole-body MRI to the FDG-PET-CT considered as the gold-standard and measure sensibility/specificity and diagnostic accuracy of the whole-body MRI for distant lesions of rectal cancer.

Outcome Time Frame:

baseline and 1 week before surgery

Safety Issue:

No

Principal Investigator

Milena Cerny

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Lausanne Hospitals

Authority:

Switzerland: Ethikkommission

Study ID:

247/12

NCT ID:

NCT01745874

Start Date:

October 2012

Completion Date:

October 2013

Related Keywords:

  • Rectal Cancer
  • Rectal cancer
  • Whole-body MRI
  • FDG-PET-CT
  • preoperative staging
  • Rectal Neoplasms

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