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Adipose Tissue Angiogenesis in Polycystic Ovary Syndrome (PCOS)

20 Years
40 Years
Open (Enrolling)
Polycystic Ovary Syndrome, Metabolic Diseases, Overweight

Thank you

Trial Information

Adipose Tissue Angiogenesis in Polycystic Ovary Syndrome (PCOS)

Epigenetics may represent a new regulator mechanism explaining gluteal vs. abdominal fat

Inclusion Criteria:

- Female

- Age > 20 and < 40

- Weight stable (change of less than 3 kg in the last 8 weeks), and within 10% of peak
body weight (not including pregnancy).

- BMI < 40 kg/m2 or > 30 kg/m2

Supplemental inclusion criteria for PCOS women:

- NIH criteria - confirmed by subjects' medical records.

Exclusion Criteria:

- Male

- Women who are pregnant or lactating (breast feeding)

- Post-menopausal women

- Women with hysterectomy

- Diagnosed with diabetes, or have a fasting blood sugar > 126 mg/dL.

- Untreated or symptomatic thyroid disease.

- Impaired kidney or liver function, as evidenced by your blood work

- Hypertension/ high blood pressure or are taking blood pressure medications

- Use of oral contraceptives or hormone replacement therapy.

- History of drug or alcohol abuse (> 3 drinks per day) in the last 5 years, or
psychiatric disease prohibiting adherence to study protocol.

- History of cancer within the last 5 years.

- History of organ transplant.

- History of HIV, active Hepatitis B or C, or Tuberculosis.

- History of heart attack/ myocardial infarction.

- Presence of clinically significant abnormalities on EKG.

- Current smokers (smoking within the past 3 months)

- Use of any medications known to influence glucose, fat and/or energy metabolism
within the last 3 months (e.g., growth hormone therapy, glucocorticoids [steroids],
etc.). Metformin for women with PCOS is allowed.

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Difference of angiogenesis capacity in abdominal and gluteal adipose tissue

Outcome Description:

The angiogenesis capacity of each adipose tissue depot will be determine by an in vitro angiogenesis test.

Outcome Time Frame:

Day 7

Safety Issue:


Principal Investigator

Adeline Divoux, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Translational Research Institute for Metabolism and Diabetes


United States: Institutional Review Board

Study ID:

TRIMDFH 348525



Start Date:

December 2012

Completion Date:

December 2013

Related Keywords:

  • Polycystic Ovary Syndrome
  • Metabolic Diseases
  • Overweight
  • Abdominal Adipose
  • Gluteal Adipose
  • Polycystic Ovary Syndrome
  • Obesity
  • Women
  • Metabolic Diseases
  • Polycystic Ovary Syndrome
  • Overweight



Translational Research Institute for Metabolism and DiabetesOrlando, Florida  32804