Effects of Thyroid Hormone Withdrawal on Metabolic and Cardiovascular Parameters During Radioactive Iodine Therapy in Differentiated Thyroid Cancer
1. Study design measurement of various parameters during hypothyroid state (before 1
month, the day and after 1 month of RAI therapy)
2. Measurements
1. Measurement of metabolic and cardiovascular parameters
- glucose profiles : HbA1c, fasting glucose level
- lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol,
triglyceride
- adipocytokines : retinol binding protein(RBP)
- 4, leptin, resistin, adiponectin
- markers of endothelial and cardiac function : high-sensitivity C-reactive
protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
- bone turnover markers : CTX, bone ALP
2. Scoring of symptoms and signs of hypothyroidism (Zulewski score)
- symptoms
- physical signs
Observational
Observational Model: Case-Only, Time Perspective: Prospective
Changes of metabolic parameters
glucose profiles : HbA1c, fasting glucose level lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride adipocytokines : retinol binding protein(RBP)4, leptin, resistin, adiponectin markers of endothelial and cardiac function : high-sensitivity C-reactive - protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine therapy
No
Suk Kyeong Kim, MD, PhD
Principal Investigator
Konkuk University Medical Center
South Korea: Institutional Review Board
KUH1010379
NCT01744769
July 2012
May 2013
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