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20 Years
70 Years
Not Enrolling
Prostate Cancer

Thank you

Trial Information

Inclusion Criteria:

1. ASA class 1 or 2

2. Adults over the age of 20 and under 70

3. Patients undergoing robot-assisted laparoscopic radical prostatectomy

4. Patients that have given informed consent

Exclusion Criteria:

1. Patients with known ophthalmic diseases (glaucoma, diabetic retinopathy, cataract,
retinal detachment)

2. Patients with history of ophthalmic surgery

3. Patients with high baseline intraocular pressure (over 30 mmHg)

4. Patients with active cardiac conditions (unstable angina, congestive heart failure)

5. Patients with uncontrolled hypertension (diastolic blood pressure > 110 mmHg)

6. Patients with history of allergic reactions to propofol

7. Illiterate patients

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Outcome Measure:

Intraocular pressure

Outcome Description:

Before induction of anesthesia (T0), 5 minutes after induction of anesthesia (T1), 5 minutes after pneumoperitoneum (T2), 30 minutes after steep Trendelenburg position with pneumoperitoneum (T3), 5 minutes after returning to horizontal position with pneumoperitoneum (T4), 5 minutes after desufflation (T5), 5 minutes after awakening in the operating room (T6), 60 minutes after awakening in the recovery room (T7), 24 hours after the operation (T9)

Outcome Time Frame:

Changes in intraocular pressure during pneumoperitoneum in the steep Trendelenburg position

Safety Issue:



Korea: Institutional Review Board

Study ID:




Start Date:

May 2011

Completion Date:

March 2012

Related Keywords:

  • Prostate Cancer
  • intraocular pressure, total intravenous anesthesia, laparoscopic prostatectomy
  • Prostatic Neoplasms