Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
- Infants under 6 months
- Presenting a hemangioma with the following characteristics:
- subcutaneous and / or cutaneous
- minimum diameter of 1.5cm on face, 5cm outside face and 3cm if it is ulcerated.
- without functional impairment requiring treatment or vital corticosteroid
- Consent of both parents (or the person having parental authority in families)
- Which at least one parent is a beneficiary of a social security system.
- Indication of treatment with corticosteroids for an indication other than hemangioma
- Indication of treatment with beta-blocker for another indication that the hemangioma
- Infant presenting cons-indications for the administration of acebutolol or
- Asthma and chronic obstructive pulmonary disease in their severe forms.
- Heart failure controlled by treatment.
- Cardiogenic shock
- Prinzmetal Angina
- Bradycardia (<80 beats / min at rest the first month <70/minute from 1 to 6
- Raynaud's phenomenon and peripheral arterial disorders in their severe forms.
- Pheochromocytoma untreated.
- Low blood pressure (blood pressure <60/30 mmHg before 6 months)
- Hypersensitivity to acebutolol or propranolol
- History of anaphylactic reaction.
- Treatment with amiodarone and / or calcium channel blockers.
- Congenital heart disease outside inter auricular communication (CIA) or inter
ventricular communication (CIV) insignificant