Effect of Neoadjuvant Chemotherapy on Muscle Mass and Peri-operative Cardiorespiratory Performance in Patients Undergoing Oesophageal Cancer- a Pilot Study
18 Years
N/A
Both
Oesophageal Adenocarcinoma
Trial Information
Effect of Neoadjuvant Chemotherapy on Muscle Mass and Peri-operative Cardiorespiratory Performance in Patients Undergoing Oesophageal Cancer- a Pilot Study
We aim to review the effects of chemotherapy on skeletal muscle mass and cardio-respiratory
performance in patients with oesophageal adenocarcinoma. All patients will be assessed by a
Consultant Anaesthetist and a medical member of the Research team before commencing
chemotherapy and after finishing their course. These assessments include a nutritional
assessment, performance status assessments, blood assays, dual energy X-ray absorptiometry
(DEXA) scans, cardio-pulmonary exercise (CPEX) testing and a muscle biopsy.
Inclusion Criteria:
- oesophageal cancer
- Multidisciplinary team decision to offer neoadjuvant chemotherapy prior to surgery
Exclusion Criteria:
- Metastatic disease
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
muscle mass
Outcome Description:
variations in muscle mass during neoadjuvant chemotherapy
Outcome Time Frame:
3 months
Safety Issue:
No
Principal Investigator
John Williams, MBChB, FFPMRCA, PhD
Investigator Role:
Study Chair
Investigator Affiliation:
Graduate Entry Medical School, University of Nottingham
Authority:
United Kingdom: National Health Service
Study ID:
10/H0405/38
NCT ID:
NCT01742312
Start Date:
October 2011
Completion Date:
November 2013
Related Keywords:
- Oesophageal Adenocarcinoma
- neoadjuvant chemotherapy
- oesophageal cancer
- cardiorespiratory performance
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Esophageal Diseases
- Esophageal Neoplasms
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