Coagulation Profile in Patients Undergoing Video Assisted Thorascopic Surgery (VATS) for Lung Cancer - A Randomized, Controlled Trial
Lung cancer is a serious and very frequent disease. For those 25% of the patients who will
undergo surgery, there are two different methods of operation: either open surgery
(thoracotomy) or Video Assisted Thorascopic Surgery (VATS). The latter method is increasing
Patients are often prescribed heparin pre- postoperatively, but it is unclear whether this
prophylactic treatment is necessary, and it has never been thoroughly investigated.
When patients receive heparin there is an increased risk of bleeding.
Furthermore, it is unclear what changes occurs in the coagulation system pre, per- and
postoperatively in patients undergoing surgery for lung-cancer, and hereby it is unclear
whether these patients should have some sort of medical prophylactic treatment.
By using new analysis methods in terms of Thromboelastometry, Thrombin generation and
thrombocyte function analysis, hereby the total coagulation profile can be characterized and
hereby estimate the risk of thrombosis and bleeding. Thereby better be able to give the
right treatment for these patients.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Analysis of in-tem, ex-tem, fib-tem og hep-tem and estimation of: Clotting time (CT (sec)), propagation (MaxVel (mm*100/sec) t,MaxVel, s) og termination (maximum clot firmness (MCF)(mm*100/sec)
Thomas D Christensen, MD
Aarhus University Hospital
Denmark: Ethics Committee
COPPVATS vs 1.1